Future Scenarios for Levodopa-Induced Dyskinesias in Parkinson’s Disease
نویسندگان
چکیده
1 IBFM, National Research Council, Catanzaro, Italy 2 Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS, Rome, Italy 3 Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson’s Disease, Division of Neurology, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, Canada 4 Dipartimento di Medicina Clinica e Sperimentale, Università di Messina, Messina, Italy *Correspondence: [email protected]
منابع مشابه
Betaine protects cerebellum from oxidative stress following levodopa and benserazide administration in rats
Objective(s): The aim of the present study was to evaluate antioxidant and methyl donor effects of betaine in cerebellum following levodopa and benserazide administration in rats. Materials and Methods: Sprague-Dawley male rats were treated with levodopa (LD), betaine (Bet), levodopa plus betaine (LD/Bet), levodopa plus benserazide (LD/Ben), levodopa plus betaine-benserazide (LD/Bet-Ben), and t...
متن کاملNeurodegenerative Disease Parkinson’s Disease
Oral levodopa remains the most effective symptomatic drug for Parkinson’s disease (PD); however, its long-term use is limited by the emergence of motor fluctuations and involuntary movements, particularly in young-onset patients. A growing number of pre-clinical and clinical studies suggest that non-physiological pulsatile stimulation of striatal dopamine (DA) receptors induced by the use of sh...
متن کاملOp-brai150098 1658..1666
Dopaminergic signalling in the striatum contributes to reinforcement of actions and motivational enhancement of motor vigour. Parkinson’s disease leads to progressive dopaminergic denervation of the striatum, impairing the function of cortico-basal ganglia networks. While levodopa therapy alleviates basal ganglia dysfunction in Parkinson’s disease, it often elicits involuntary movements, referr...
متن کاملOp-brai150098 1..9
Dopaminergic signalling in the striatum contributes to reinforcement of actions and motivational enhancement of motor vigour. Parkinson’s disease leads to progressive dopaminergic denervation of the striatum, impairing the function of cortico-basal ganglia networks. While levodopa therapy alleviates basal ganglia dysfunction in Parkinson’s disease, it often elicits involuntary movements, referr...
متن کاملLevodopa-induced Dyskinesias and Their Management N Epidemiology
Following a period of stable response to dopaminergic medication (the “honeymoon” period), Parkinson’s disease (PD) patients gradually develop two progressive clinical phenomena requiring changes in the clinical management: motor fluctuations and dyskinesias. These two phenomena are intrinsically interconnected, but often require opposite treatment attitudes, because increases of dopaminergic t...
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2015